Glucosamine has been tested on humans and animals. Safety has not been proven. Some of these conditions are potentially very serious and you should be evaluated by a health care professional.

Knee osteo arthritis (mild-to-moderate)
(A Rating)

According to human research, there’s good evidence to aid using glucosamine sulfate in treating mild-to-moderate knee osteo arthritis. Most research has used glucosamine sulfate provided by one European manufacturer (Rotta Research Laboratorium), which is unfamiliar if glucosamine formulations produced by other producers are equally effective. Even though some studies of glucosamine haven’t found benefits, these have either incorporated patients with severe osteo arthritis or used items apart from glucosamine sulfate . Evidence for that effect of glycosaminoglycan polysulphate is conflicting and merits further analysis. More well-designed clinical tests are necessary to confirm safety and effectiveness, and also to test different formulations of glucosamine.

Osteo arthritis (general)
(B Rating)

Several scientific testing on people and animal experiments report advantages of glucosamine in dealing with osteo arthritis of numerous joints from the body, even though evidence is less plentiful than that for knee osteo arthritis. A few of these benefits include discomfort relief, possibly because of an anti-inflammatory effect of glucosamine, and enhanced joint function. Overall, these studies haven’t been smartly designed. Although there’s some promising research, more study is required in this region before a strong conclusion can be created.

Chronic venous deficit
(B Rating)

“Chronic venous deficit” is really a syndrome which includes leg swelling, spider veins, discomfort, itchiness, skin changes, and skin stomach problems. The word is much more generally utilized in Europe compared to the U . s . States. Presently, there’s insufficient reliable scientific evidence to recommend glucosamine in treating this problem. C

Diabetes (and related conditions)
(C Rating)

Early research indicates that glucosamine doesn’t improve bloodstream sugar control, fat levels, or apolipoprotein levels in diabetes sufferers. Additional scientific studies are needed in this region.

Inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
(C Rating)

Research reviews enhancements with N-acetyl glucosamine being an added therapy in inflammatory bowel disease. Further scientific evidence is essential before a powerful recommendation can be created.

Discomfort (leg discomfort)
(C Rating)

Preliminary human research reviews advantages of injected glucosamine plus chondroitin in treating leg discomfort developing from advanced lumbar degenerative disc disease. Further scientific evidence is essential before a strong recommendation can be created.

Rehab (after knee injuries)
(C Rating)

Glucosamine continues to be provided to sports athletes with acute knee injuries. Although glucosamine didn’t improve discomfort, it did help to improve versatility. Additional research is required to confirm these early findings.

Rheumatoid arthritis symptoms
(C Rating)

Early human research reviews advantages of glucosamine in treating joint discomfort and swelling in rheumatoid arthritis symptoms. In other research, glucosamine didn’t exert anti-rheumatic effects, however it did improve signs and symptoms from the disease. However, this really is early information, and extra scientific studies are needed before a conclusion could be attracted. Treating rheumatoid arthritis symptoms could be complicated, along with a qualified health care provider should follow patients with this particular disease.

Temporomandibular joint (TMJ) disorders
(C Rating)

There’s deficiencies in sufficient evidence to recommend for or against using glucosamine (or even the mixture of chondroitin and glucosamine) in treating temporomandibular joint disorders.

High cholesterol levels
(D Rating)

Glucosamine doesn’t seem to alter LDL or High-density lipoprotein levels in patients with chronic joint discomfort or diabetes.